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==TetR(D) E147A mutant in complex with anhydrotetracycline and magnesium==
==TetR(D) E147A mutant in complex with anhydrotetracycline and magnesium==
<StructureSection load='5fko' size='340' side='right' caption='[[5fko]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='5fko' size='340' side='right'caption='[[5fko]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fko]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FKO FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FKO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fkk|5fkk]], [[5fkl|5fkl]], [[5fkm|5fkm]], [[5fkn|5fkn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fko OCA], [http://pdbe.org/5fko PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fko RCSB], [http://www.ebi.ac.uk/pdbsum/5fko PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fko OCA], [https://pdbe.org/5fko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fko RCSB], [https://www.ebi.ac.uk/pdbsum/5fko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fko ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fko" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fko" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hinrichs, W]]
[[Category: Escherichia coli]]
[[Category: Palm, G J]]
[[Category: Large Structures]]
[[Category: Schneider, J]]
[[Category: Hinrichs W]]
[[Category: Werten, S]]
[[Category: Palm GJ]]
[[Category: Antibiotic resistance]]
[[Category: Schneider J]]
[[Category: Repressor]]
[[Category: Werten S]]
[[Category: Tetr]]
[[Category: Transcription]]
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