1hj0: Difference between revisions

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[[Image:1hj0.jpg|left|200px]]


{{Structure
==Thymosin beta9==
|PDB= 1hj0 |SIZE=350|CAPTION= <scene name='initialview01'>1hj0</scene>
<StructureSection load='1hj0' size='340' side='right'caption='[[1hj0]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1hj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJ0 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hj0 OCA], [https://pdbe.org/1hj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hj0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hj0 ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hj0 OCA], [http://www.ebi.ac.uk/pdbsum/1hj0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hj0 RCSB]</span>
[https://www.uniprot.org/uniprot/TYB10_BOVIN TYB10_BOVIN] Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''THYMOSIN BETA9'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/1hj0_consurf.spt"</scriptWhenChecked>
==Overview==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
The conformation of thymosin beta 9 in solution of 40% (v/v) 1,1,1,3,3,3-hexafluoro-2-propanol-d2 in water has been investigated by two-dimensional 1H-nmr spectroscopy. Under this condition thymosin beta 9 adopts an ordered structure. The determination of the conformation of the peptide was based on a set of 304 approximate interproton distance constraints derived from nuclear Overhauser enhancement measurements. The conformation of thymosin beta 9 includes two helical regions from residues 4 to 27 and 32 to 41. The two helices are separated by a poorly defined loop region between amino acids 28 and 31; the N-terminus of thymosin beta 9 shows random-coil structure only.
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hj0 ConSurf].
1HJ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJ0 OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy., Stoll R, Voelter W, Holak TA, Biopolymers. 1997 May;41(6):623-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9108730 9108730]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Holak, T A.]]
[[Category: Holak TA]]
[[Category: Stoll, R.]]
[[Category: Stoll R]]
[[Category: Voelter, W.]]
[[Category: Voelter W]]
[[Category: actin]]
[[Category: immunopotentiation]]
[[Category: t-cell differentiation]]
[[Category: thymus]]
 
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Retrieved from "https://proteopedia.org/1hj0"