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==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand (DDD85646)==
==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand (DDD85646)==
<StructureSection load='4cax' size='340' side='right' caption='[[4cax]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4cax' size='340' side='right'caption='[[4cax]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cax]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=646:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>646</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cav|4cav]], [[4caw|4caw]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=646:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>646</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cax OCA], [https://pdbe.org/4cax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cax RCSB], [https://www.ebi.ac.uk/pdbsum/4cax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cax ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cax OCA], [http://pdbe.org/4cax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cax RCSB], [http://www.ebi.ac.uk/pdbsum/4cax PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.  
[https://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Aspergillus fumigatus]]
[[Category: Aalten, D M.F Van]]
[[Category: Large Structures]]
[[Category: Blair, D E]]
[[Category: Blair DE]]
[[Category: Fang, W]]
[[Category: Fang W]]
[[Category: Gilbert, I H]]
[[Category: Gilbert IH]]
[[Category: Harrison, J]]
[[Category: Harrison J]]
[[Category: Lockhart, D E.A]]
[[Category: Lockhart DEA]]
[[Category: Raimi, O G]]
[[Category: Raimi OG]]
[[Category: Robinson, D A]]
[[Category: Robinson DA]]
[[Category: Ruda, G F]]
[[Category: Ruda GF]]
[[Category: Torrie, L S]]
[[Category: Torrie LS]]
[[Category: Wyatt, P G]]
[[Category: Van Aalten DMF]]
[[Category: Drug discovery]]
[[Category: Wyatt PG]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4cax"