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==Crystal structure of SGF29 tandem tudor domain in complex with a Carba containing peptide==
==Crystal structure of SGF29 tandem tudor domain in complex with a Carba containing peptide==
<StructureSection load='5c0m' size='340' side='right' caption='[[5c0m]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5c0m' size='340' side='right'caption='[[5c0m]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5c0m]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C0M FirstGlance]. <br>
<table><tr><td colspan='2'>[[5c0m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C0M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WQ:(2S)-2-AMINO-7,7-DIMETHYLOCTANOIC+ACID'>4WQ</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4WQ:(2S)-2-AMINO-7,7-DIMETHYLOCTANOIC+ACID'>4WQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c0m OCA], [http://pdbe.org/5c0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c0m RCSB], [http://www.ebi.ac.uk/pdbsum/5c0m PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c0m OCA], [https://pdbe.org/5c0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c0m RCSB], [https://www.ebi.ac.uk/pdbsum/5c0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c0m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SGF29_HUMAN SGF29_HUMAN]] Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.<ref>PMID:19103755</ref>
[https://www.uniprot.org/uniprot/SGF29_HUMAN SGF29_HUMAN] Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.<ref>PMID:19103755</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5c0m" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5c0m" style="background-color:#fffaf0;"></div>
==See Also==
*[[SAGA-associated factor|SAGA-associated factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Homo sapiens]]
[[Category: Bountra, C]]
[[Category: Large Structures]]
[[Category: Cerovina, T]]
[[Category: Arrowsmith CH]]
[[Category: Dong, A]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Cerovina T]]
[[Category: Min, J]]
[[Category: Dong A]]
[[Category: Structural genomic]]
[[Category: Edwards AM]]
[[Category: Tempel, W]]
[[Category: Min J]]
[[Category: Xu, C]]
[[Category: Tempel W]]
[[Category: Carba containing peptide]]
[[Category: Xu C]]
[[Category: Sgc]]
[[Category: Sgf29]]
[[Category: Tandem tudor domain]]
[[Category: Transcription]]

Latest revision as of 08:33, 27 September 2023

Crystal structure of SGF29 tandem tudor domain in complex with a Carba containing peptide

5c0m, resolution 1.60Å

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