2n9f: Difference between revisions
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==Glucose as non natural nucleobase== | |||
<StructureSection load='2n9f' size='340' side='right'caption='[[2n9f]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n9f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JA:(2S)-3-[(6-DEOXY-BETA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYPROPYL+DIHYDROGEN+PHOSPHATE'>4JA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9f OCA], [https://pdbe.org/2n9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9f RCSB], [https://www.ebi.ac.uk/pdbsum/2n9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9f ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside-RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. | |||
Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA.,Vengut-Climent E, Gomez-Pinto I, Lucas R, Penalver P, Avino A, Fonseca Guerra C, Bickelhaupt FM, Eritja R, Gonzalez C, Morales JC Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8643-7. doi: 10.1002/anie.201603510., Epub 2016 Jun 22. PMID:27328804<ref>PMID:27328804</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 2n9f" style="background-color:#fffaf0;"></div> | ||
[[Category: Bickelhaupt | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Gonzalez-Ibanez | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Avino A]] | ||
[[Category: | [[Category: Bickelhaupt M]] | ||
[[Category: | [[Category: Eritja R]] | ||
[[Category: Fonseca-Guerra C]] | |||
[[Category: Gomez-Pinto I]] | |||
[[Category: Gonzalez-Ibanez C]] | |||
[[Category: Lucas R]] | |||
[[Category: Morales J]] | |||
[[Category: Penalver P]] | |||
[[Category: Vengut-Climent E]] | |||
Latest revision as of 09:58, 14 June 2023
Glucose as non natural nucleobase
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