2nc0: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: '''Unreleased structure''' The entry 2nc0 is ON HOLD until Paper Publication Authors: Imai, S., D'Souza, V., Wagner, G. Description: Solution structure of the St domain of EMCV IRES [[...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 2nc0 is ON HOLD  until Paper Publication
==Solution structure of the St domain of EMCV IRES==
<StructureSection load='2nc0' size='340' side='right'caption='[[2nc0]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2nc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NC0 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nc0 OCA], [https://pdbe.org/2nc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2nc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nc0 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Many viruses bypass canonical cap-dependent translation in host cells by using internal ribosomal entry sites (IRESs) in their transcripts; IRESs hijack initiation factors for the assembly of initiation complexes. However, it is currently unknown how IRES RNAs recognize initiation factors that have no endogenous RNA binding partners; in a prominent example, the IRES of encephalomyocarditis virus (EMCV) interacts with the HEAT-1 domain of eukaryotic initiation factor 4G (eIF4G). Here we report the solution structure of the J-K region of this IRES and show that its stems are precisely organized to position protein-recognition bulges. This multisite interaction mechanism operates on an all-or-nothing principle in which all domains are required. This preorganization is accomplished by an 'adjuster module': a pentaloop motif that acts as a dual-sided docking station for base-pair receptors. Because subtle changes in the orientation abrogate protein capture, our study highlights how a viral RNA acquires affinity for a target protein.


Authors: Imai, S., D'Souza, V., Wagner, G.
An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation.,Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G Nat Struct Mol Biol. 2016 Sep;23(9):859-64. doi: 10.1038/nsmb.3280. Epub 2016 Aug, 15. PMID:27525590<ref>PMID:27525590</ref>


Description: Solution structure of the St domain of EMCV IRES
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Imai, S]]
<div class="pdbe-citations 2nc0" style="background-color:#fffaf0;"></div>
[[Category: Wagner, G]]
== References ==
[[Category: D'Souza, V]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: D'Souza V]]
[[Category: Imai S]]
[[Category: Wagner G]]
Retrieved from "https://proteopedia.org/2nc0"