2rvp: Difference between revisions
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New page: '''Unreleased structure''' The entry 2rvp is ON HOLD until Mar 21 2018 Authors: Dairaku, T., Furuita, K., Sato, H., Sebera, J., Nakashima, K., Kondo, J., Yamanaka, D., Kondo, Y., Okamot... |
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==Solution structure of DNA Containing Metallo-Base-Pair== | |||
<StructureSection load='2rvp' size='340' side='right'caption='[[2rvp]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2rvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RVP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rvp OCA], [https://pdbe.org/2rvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rvp RCSB], [https://www.ebi.ac.uk/pdbsum/2rvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rvp ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of an Ag(I) -mediated cytosine-cytosine base pair, C-Ag(I) -C, was determined with NMR spectroscopy in solution. The observation of 1-bond (15) N-(109) Ag J-coupling ((1) J((15) N,(109) Ag): 83 and 84 Hz) recorded within the C-Ag(I) -C base pair evidenced the N3-Ag(I) -N3 linkage in C-Ag(I) -C. The triplet resonances of the N4 atoms in C-Ag(I) -C demonstrated that each exocyclic N4 atom exists as an amino group (-NH2 ), and any isomerization and/or N4-Ag(I) bonding can be excluded. The 3D structure of Ag(I) -DNA complex determined with NOEs was classified as a B-form conformation with a notable propeller twist of C-Ag(I) -C (-18.3+/-3.0 degrees ). The (109) Ag NMR chemical shift of C-Ag(I) -C was recorded for cytidine/Ag(I) complex (delta((109) Ag): 442 ppm) to completed full NMR characterization of the metal linkage. The structural interpretation of NMR data with quantum mechanical calculations corroborated the structure of the C-Ag(I) -C base pair. | |||
Structure Determination of an Ag(I) -Mediated Cytosine-Cytosine Base Pair within DNA Duplex in Solution with (1) H/(15) N/(109) Ag NMR Spectroscopy.,Dairaku T, Furuita K, Sato H, Sebera J, Nakashima K, Kondo J, Yamanaka D, Kondo Y, Okamoto I, Ono A, Sychrovsky V, Kojima C, Tanaka Y Chemistry. 2016 Sep 5;22(37):13028-31. doi: 10.1002/chem.201603048. Epub 2016 Aug, 9. PMID:27505707<ref>PMID:27505707</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 2rvp" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Dairaku T]] | ||
[[Category: | [[Category: Furuita K]] | ||
[[Category: | [[Category: Kojima C]] | ||
[[Category: | [[Category: Kondo J]] | ||
[[Category: | [[Category: Kondo Y]] | ||
[[Category: | [[Category: Nakashima K]] | ||
[[Category: Okamoto I]] | |||
[[Category: Ono A]] | |||
[[Category: Sato H]] | |||
[[Category: Sebera J]] | |||
[[Category: Sychrovsky V]] | |||
[[Category: Tanaka Y]] | |||
[[Category: Yamanaka D]] | |||
Latest revision as of 20:54, 12 April 2023
Solution structure of DNA Containing Metallo-Base-Pair
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