5fzi: Difference between revisions
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New page: '''Unreleased structure''' The entry 5fzi is ON HOLD until Paper Publication Authors: Nowak, R., Kopec, J., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A.,... |
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==Crystal structure of the catalytic domain of human JARID1B in complex with MC3095== | |||
<StructureSection load='5fzi' size='340' side='right'caption='[[5fzi]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fzi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FIG:6-OXO-2-[(2-OXO-2-PHENYLETHYL)SULFANYL]-1,6-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>FIG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzi OCA], [https://pdbe.org/5fzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzi RCSB], [https://www.ebi.ac.uk/pdbsum/5fzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzi ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | |||
==See Also== | |||
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | |||
*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]] | |||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Burgess-Brown | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Burgess-Brown NA]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Gileadi C]] | ||
[[Category: | [[Category: Johansson C]] | ||
[[Category: | [[Category: Kopec J]] | ||
[[Category: | [[Category: Kupinska K]] | ||
[[Category: | [[Category: Mai A]] | ||
[[Category: | [[Category: Nowak R]] | ||
[[Category: Oppermann U]] | |||
[[Category: Rotili D]] | |||
[[Category: Strain-Damerell C]] | |||
[[Category: Szykowska A]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 13:33, 26 July 2023
Crystal structure of the catalytic domain of human JARID1B in complex with MC3095
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