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[[Image:1huu.jpg|left|200px]]


{{Structure
==DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS==
|PDB= 1huu |SIZE=350|CAPTION= <scene name='initialview01'>1huu</scene>, resolution 2.0&Aring;
<StructureSection load='1huu' size='340' side='right'caption='[[1huu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1huu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HUU FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1huu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huu OCA], [https://pdbe.org/1huu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1huu RCSB], [https://www.ebi.ac.uk/pdbsum/1huu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1huu ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1huu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huu OCA], [http://www.ebi.ac.uk/pdbsum/1huu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1huu RCSB]</span>
[https://www.uniprot.org/uniprot/DBH_GEOSE DBH_GEOSE] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/1huu_consurf.spt"</scriptWhenChecked>
==Overview==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1huu ConSurf].
1HUU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
A protein structural motif that bends DNA., White SW, Appelt K, Wilson KS, Tanaka I, Proteins. 1989;5(4):281-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2508086 2508086]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Appelt, K.]]
[[Category: Appelt K]]
[[Category: Tanaka, I.]]
[[Category: Tanaka I]]
[[Category: White, S W.]]
[[Category: White SW]]
[[Category: Wilson, K S.]]
[[Category: Wilson KS]]
[[Category: alpha/beta class]]
[[Category: dna supercoiling]]
[[Category: dna-binding protein]]
[[Category: minor groove binder]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:45 2008''

Latest revision as of 07:30, 7 February 2024

DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS

1huu, resolution 2.00Å

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