5j4a: Difference between revisions
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New page: '''Unreleased structure''' The entry 5j4a is ON HOLD until Paper Publication Authors: Goulding, C.W., Johnson, P.M. Description: CdiA-CT toxin from Burkholderia pseudomallei E479 in co... |
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==CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein== | |||
<StructureSection load='5j4a' size='340' side='right'caption='[[5j4a]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5j4a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J4A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4a OCA], [https://pdbe.org/5j4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j4a RCSB], [https://www.ebi.ac.uk/pdbsum/5j4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4a ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/CDIA9_BURPE CDIA9_BURPE] Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. The C-terminal 160 residues (CT domain) acts as a general tRNA nuclease, and inhibits growth in E.coli. Cleaves specifically within the T-loop of E.coli tRNA2(Arg). Toxic activity is neutralized by coexpression of the cognate immunity protein CdiI in E.coli, but not by non-cognate immunity proteins from other strains of B.pseudomallei.<ref>PMID:22435733</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Burkholderia pseudomallei]] | |||
[[Category: Large Structures]] | |||
[[Category: Goulding CW]] | |||
[[Category: Johnson PM]] | |||
Latest revision as of 12:36, 6 March 2024
CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein
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