5j4f: Difference between revisions

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New page: '''Unreleased structure''' The entry 5j4f is ON HOLD until Paper Publication Authors: Sim, D.-W., Lee, W.-C., Kim, H.Y., Kim, J.-H., Won, H.-S. Description: [[Category: Unreleased Str...
 
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'''Unreleased structure'''


The entry 5j4f is ON HOLD  until Paper Publication
==Crystal structure of the N-terminally His6-tagged HP0902, an uncharacterized protein from Helicobacter pylori 26695==
<StructureSection load='5j4f' size='340' side='right'caption='[[5j4f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5j4f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J4F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4f OCA], [https://pdbe.org/5j4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j4f RCSB], [https://www.ebi.ac.uk/pdbsum/5j4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O25562_HELPY O25562_HELPY]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We solved the crystal structure of a functionally uncharacterized protein, HP0902, from Helicobacter pylori. Its structure demonstrated an all-beta cupin fold that cannot bind metal ions due to the absence of a metal-binding histidine that is conserved in many metallo-cupins. In contrast, isothermal titration calorimetry and NMR titration demonstrated that HP0902 is able to bind bacterial endotoxin lipopolysaccharides (LPS) through its surface-exposed loops, where metal-binding sites are usually found in other metallo-cupins. This report constitutes the first identification of an LPS-interacting protein, both in the cupin family and in H. pylori. Furthermore, identification of the ability of HP0902 to bind LPS uncovers a putative role for this protein in H. pylori pathogenicity.


Authors: Sim, D.-W., Lee, W.-C., Kim, H.Y., Kim, J.-H., Won, H.-S.
Structural identification of the lipopolysaccharide-binding capability of a cupin-family protein from Helicobacter pylori.,Sim DW, Kim JH, Kim HY, Jang JH, Lee WC, Kim EH, Park PJ, Lee KH, Won HS FEBS Lett. 2016 Sep;590(17):2997-3004. doi: 10.1002/1873-3468.12332. Epub 2016, Aug 11. PMID:27466800<ref>PMID:27466800</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Sim, D.-W]]
<div class="pdbe-citations 5j4f" style="background-color:#fffaf0;"></div>
[[Category: Kim, H.Y]]
== References ==
[[Category: Won, H.-S]]
<references/>
[[Category: Kim, J.-H]]
__TOC__
[[Category: Lee, W.-C]]
</StructureSection>
[[Category: Helicobacter pylori 26695]]
[[Category: Large Structures]]
[[Category: Kim HY]]
[[Category: Kim J-H]]
[[Category: Lee W-C]]
[[Category: Sim D-W]]
[[Category: Won H-S]]
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