5j99: Difference between revisions
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New page: '''Unreleased structure''' The entry 5j99 is ON HOLD until Paper Publication Authors: Godsey, M., Davulcu, O., Nix, J., Skalicky, J.J., Bruschweiler, R., Chapman, M.S. Description: Amb... |
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==Ambient temperature transition state structure of arginine kinase - crystal 8/Form I== | |||
<StructureSection load='5j99' size='340' side='right'caption='[[5j99]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5j99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J99 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j99 OCA], [https://pdbe.org/5j99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j99 RCSB], [https://www.ebi.ac.uk/pdbsum/5j99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j99 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KARG_LIMPO KARG_LIMPO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Arginine kinase provides a model for functional dynamics, studied through crystallography, enzymology, and nuclear magnetic resonance. Structures are now solved, at ambient temperature, for the transition state analog (TSA) complex. Analysis of quasi-rigid sub-domain displacements show that differences between the two TSA structures average about 5% of changes between substrate-free and TSA forms, and they are nearly co-linear. Small backbone hinge rotations map to sites that also flex on substrate binding. Anisotropic atomic displacement parameters (ADPs) are refined using rigid-body TLS constraints. Consistency between crystal forms shows that they reflect intrinsic molecular properties more than crystal lattice effects. In many regions, the favored directions of thermal/static displacement are appreciably correlated with movements on substrate binding. Correlation between ADPs and larger substrate-associated movements implies that the latter approximately follow paths of low-energy intrinsic motions. | |||
The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase.,Godsey MH, Davulcu O, Nix JC, Skalicky JJ, Bruschweiler RP, Chapman MS Structure. 2016 Sep 1. pii: S0969-2126(16)30224-6. doi:, 10.1016/j.str.2016.07.013. PMID:27594681<ref>PMID:27594681</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5j99" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: Davulcu | ==See Also== | ||
[[Category: | *[[Arginine kinase 3D structures|Arginine kinase 3D structures]] | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Limulus polyphemus]] | |||
[[Category: Bruschweiler R]] | |||
[[Category: Chapman MS]] | |||
[[Category: Davulcu O]] | |||
[[Category: Godsey M]] | |||
[[Category: Nix J]] | |||
[[Category: Skalicky JJ]] | |||
Latest revision as of 10:55, 6 September 2023
Ambient temperature transition state structure of arginine kinase - crystal 8/Form I
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