5jer: Difference between revisions
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New page: '''Unreleased structure''' The entry 5jer is ON HOLD Authors: Zhao, B., Li, P. Description: Category: Unreleased Structures Category: Zhao, B Category: Li, P |
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==Structure of Rotavirus NSP1 bound to IRF-3== | |||
<StructureSection load='5jer' size='340' side='right'caption='[[5jer]], [[Resolution|resolution]] 2.91Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jer]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rotavirus_A Rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JER FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.913Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jer OCA], [https://pdbe.org/5jer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jer RCSB], [https://www.ebi.ac.uk/pdbsum/5jer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jer ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NSP1_ROTS4 NSP1_ROTS4] Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.[HAMAP-Rule:MF_04088]<ref>PMID:15741273</ref> <ref>PMID:17251580</ref> <ref>PMID:17301153</ref> <ref>PMID:27099313</ref> <ref>PMID:27302953</ref> | |||
==See Also== | |||
*[[Interferon regulatory factor|Interferon regulatory factor]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Li | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Rotavirus A]] | |||
[[Category: Li P]] | |||
[[Category: Zhao B]] | |||
