5jgm: Difference between revisions

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'''Unreleased structure'''


The entry 5jgm is ON HOLD  until Paper Publication
==tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate==
<StructureSection load='5jgm' size='340' side='right'caption='[[5jgm]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jgm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JGM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=810:ETHYL+[2-(METHYLAMINO)-8-OXO-7,8-DIHYDRO-1H-IMIDAZO[4,5-G]QUINAZOLIN-6-YL]CARBAMATE'>810</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgm OCA], [https://pdbe.org/5jgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jgm RCSB], [https://www.ebi.ac.uk/pdbsum/5jgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]


Authors: Ehrmann, F.R., Nguyen, D., Heine, A., Klebe, G.
==See Also==
 
*[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]]
Description: tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Klebe, G]]
[[Category: Large Structures]]
[[Category: Ehrmann, F.R]]
[[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]]
[[Category: Heine, A]]
[[Category: Ehrmann FR]]
[[Category: Nguyen, D]]
[[Category: Heine A]]
[[Category: Klebe G]]
[[Category: Nguyen D]]
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