5jhl: Difference between revisions
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New page: '''Unreleased structure''' The entry 5jhl is ON HOLD Authors: Dai, L., Shi, Y., Qi, J., Gao, G.F. Description: Crystal structure of zika virus envelope protein in complex with a flaviv... |
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The entry | ==Crystal structure of zika virus envelope protein in complex with a flavivirus broadly-protective antibody== | ||
<StructureSection load='5jhl' size='340' side='right'caption='[[5jhl]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jhl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhl OCA], [https://pdbe.org/5jhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jhl RCSB], [https://www.ebi.ac.uk/pdbsum/5jhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0X9QZM7_ZIKV A0A0X9QZM7_ZIKV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. Here, we report the structures of ZIKV E protein at 2.0 A and in complex with a flavivirus broadly neutralizing murine antibody 2A10G6 at 3.0 A. ZIKV-E resembles all the known flavivirus E structures but contains a unique, positively charged patch adjacent to the fusion loop region of the juxtaposed monomer, which may influence host attachment. The ZIKV-E-2A10G6 complex structure reveals antibody recognition of a highly conserved fusion loop. 2A10G6 binds to ZIKV-E with high affinity in vitro and neutralizes currently circulating ZIKV strains in vitro and in mice. The E protein fusion loop epitope represents a potential candidate for therapeutic antibodies against ZIKV. | |||
Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody.,Dai L, Song J, Lu X, Deng YQ, Musyoki AM, Cheng H, Zhang Y, Yuan Y, Song H, Haywood J, Xiao H, Yan J, Shi Y, Qin CF, Qi J, Gao GF Cell Host Microbe. 2016 May 11;19(5):696-704. doi: 10.1016/j.chom.2016.04.013., Epub 2016 May 2. PMID:27158114<ref>PMID:27158114</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5jhl" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: Dai | ==See Also== | ||
[[Category: Qi | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[3D structures of non-human antibody|3D structures of non-human antibody]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Zika virus]] | |||
[[Category: Dai L]] | |||
[[Category: Gao GF]] | |||
[[Category: Qi J]] | |||
[[Category: Shi Y]] | |||
Latest revision as of 11:52, 6 November 2024
Crystal structure of zika virus envelope protein in complex with a flavivirus broadly-protective antibody
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