5ftu: Difference between revisions

<StructureSection load='5ftu' size='340' side='right' caption='[[5ftu]], [[Resolution|resolution]] 6.01&Aring;' scene=''>

<table><tr><td colspan='2'>[[5ftu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FTU FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ftt|5ftt]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ftu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftu OCA], [http://pdbe.org/5ftu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ftu RCSB], [http://www.ebi.ac.uk/pdbsum/5ftu PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/UNC5D_RAT UNC5D_RAT]] Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).[UniProtKB:Q6UXZ4][UniProtKB:Q8K1S2] [[http://www.uniprot.org/uniprot/AGRL3_MOUSE AGRL3_MOUSE]] Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570).<ref>PMID:22405201</ref> <ref>PMID:24739570</ref> <ref>PMID:25728924</ref> <ref>PMID:26235031</ref>  [[http://www.uniprot.org/uniprot/FLRT2_MOUSE FLRT2_MOUSE]] Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:21350012, PubMed:25728924 PubMed:25374360). May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D (PubMed:21673655). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25728924). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis (PubMed:21350012).<ref>PMID:16872596</ref> <ref>PMID:21350012</ref> <ref>PMID:21673655</ref> <ref>PMID:25374360</ref> <ref>PMID:25728924</ref> 

[[Category: Carrasquero, M]]

[[Category: Chavent, M]]

[[Category: Comoletti, D]]

[[Category: Jackson, V A]]

[[Category: Ranaivoson, F M]]

[[Category: Robinson, C V]]

[[Category: Sansom, M S.P]]

[[Category: Seiradake, E]]

[[Category: Toro, D del]]

[[Category: Adhesion]]

[[Category: Apoptosis]]

[[Category: Beta propellor]]

[[Category: Flrt]]

[[Category: Guidance]]

[[Category: Immunoglobulin]]

[[Category: Latrophilin]]

[[Category: Lectin]]

[[Category: Leucine-rich repeat]]

[[Category: Lrr]]

[[Category: Uncoordinated-5]]