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==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds==
==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds==
<StructureSection load='4yqc' size='340' side='right' caption='[[4yqc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='4yqc' size='340' side='right'caption='[[4yqc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yqc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EFW:6-{[(1R,3R)-3-HYDROXYCYCLOPENTYL]AMINO}PYRIDINE-3-CARBOXAMIDE'>EFW</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EFW:6-{[(1R,3R)-3-HYDROXYCYCLOPENTYL]AMINO}PYRIDINE-3-CARBOXAMIDE'>EFW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqc OCA], [http://pdbe.org/4yqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqc RCSB], [http://www.ebi.ac.uk/pdbsum/4yqc PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqc OCA], [https://pdbe.org/4yqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yqc RCSB], [https://www.ebi.ac.uk/pdbsum/4yqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]  
[https://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
 
==See Also==
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bonnette, W G]]
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Elkins, P A]]
[[Category: Large Structures]]
[[Category: Stuckey, J A]]
[[Category: Bonnette WG]]
[[Category: Knot]]
[[Category: Elkins PA]]
[[Category: Sam-binding]]
[[Category: Stuckey JA]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Trmd]]

Latest revision as of 08:04, 27 September 2023

Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds

4yqc, resolution 1.89Å

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