5j1w: Difference between revisions
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==Crystal structure of human CLK1 in complex with pyrido[3,4-g]quinazoline derivative ZW31 (compound 14)== | ==Crystal structure of human CLK1 in complex with pyrido[3,4-g]quinazoline derivative ZW31 (compound 14)== | ||
<StructureSection load='5j1w' size='340' side='right' caption='[[5j1w]], [[Resolution|resolution]] 2.42Å' scene=''> | <StructureSection load='5j1w' size='340' side='right'caption='[[5j1w]], [[Resolution|resolution]] 2.42Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5j1w]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1W OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5j1w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J1W FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FB:PYRIDO[3,4-G]QUINAZOLIN-2-AMINE'>6FB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FB:PYRIDO[3,4-G]QUINAZOLIN-2-AMINE'>6FB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1w OCA], [https://pdbe.org/5j1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j1w RCSB], [https://www.ebi.ac.uk/pdbsum/5j1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5j1w" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5j1w" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Anizon | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Anizon F]] | ||
[[Category: Boibessot | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Boibessot T]] | ||
[[Category: Chaikuad | [[Category: Bountra C]] | ||
[[Category: Chaikuad A]] | |||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Esvan | [[Category: Esvan YJ]] | ||
[[Category: Giraud | [[Category: Giraud F]] | ||
[[Category: Knapp | [[Category: Knapp S]] | ||
[[Category: Loaec | [[Category: Loaec N]] | ||
[[Category: Meijer | [[Category: Meijer L]] | ||
[[Category: Moreau | [[Category: Moreau P]] | ||
[[Category: Nauton | [[Category: Nauton L]] | ||
[[Category: Thery V]] | |||
[[Category: Thery | [[Category: Zeinyeh W]] | ||
[[Category: Zeinyeh | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 10:42, 6 September 2023
Crystal structure of human CLK1 in complex with pyrido[3,4-g]quinazoline derivative ZW31 (compound 14)
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