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==Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor==
==Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor==
<StructureSection load='4zeg' size='340' side='right' caption='[[4zeg]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='4zeg' size='340' side='right'caption='[[4zeg]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [http://pdbe.org/4zeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [http://www.ebi.ac.uk/pdbsum/4zeg PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [https://pdbe.org/4zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [https://www.ebi.ac.uk/pdbsum/4zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zeg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  
 
==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Awrey, D E]]
[[Category: Large Structures]]
[[Category: Battaile, K]]
[[Category: Awrey DE]]
[[Category: Chirgadze, N Y]]
[[Category: Battaile K]]
[[Category: Feher, M]]
[[Category: Chirgadze NY]]
[[Category: Plotnikova, O]]
[[Category: Feher M]]
[[Category: Qiu, W]]
[[Category: Plotnikova O]]
[[Category: Inhibitor]]
[[Category: Qiu W]]
[[Category: Kinase]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Ttk]]

Latest revision as of 12:15, 6 March 2024

Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor

4zeg, resolution 2.33Å

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