5hl1: Difference between revisions
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==Crystal structure of glutaminase C in complex with inhibitor CB-839== | |||
<StructureSection load='5hl1' size='340' side='right'caption='[[5hl1]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hl1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HL1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63J:2-(PYRIDIN-2-YL)-N-(5-{4-[6-({[3-(TRIFLUOROMETHOXY)PHENYL]ACETYL}AMINO)PYRIDAZIN-3-YL]BUTYL}-1,3,4-THIADIAZOL-2-YL)ACETAMIDE'>63J</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hl1 OCA], [https://pdbe.org/5hl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hl1 RCSB], [https://www.ebi.ac.uk/pdbsum/5hl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hl1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | |||
==See Also== | |||
*[[Glutaminase 3D structures|Glutaminase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Cerione | [[Category: Homo sapiens]] | ||
[[Category: Huang | [[Category: Large Structures]] | ||
[[Category: Cerione RA]] | |||
[[Category: Huang Q]] | |||
Latest revision as of 10:45, 16 August 2023
Crystal structure of glutaminase C in complex with inhibitor CB-839
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