5hso: Difference between revisions
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==Crystal structure of MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN Rv2887 complex with DNA== | |||
<StructureSection load='5hso' size='340' side='right'caption='[[5hso]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hso]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HSO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hso OCA], [https://pdbe.org/5hso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hso RCSB], [https://www.ebi.ac.uk/pdbsum/5hso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hso ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HTMR_MYCTU HTMR_MYCTU] Represses expression of the HQNO methyltransferase htm gene (Rv0560c) by binding to its promoter region (PubMed:26303802, PubMed:27432954, PubMed:28743871). Also represses the expression of at least five other genes, including the methyltransferase Rv0558 (PubMed:26303802). Binds salicylate (SA), para-aminosalicylic acid (PAS) and gemfibrozil (PubMed:28743871).<ref>PMID:26303802</ref> <ref>PMID:27432954</ref> <ref>PMID:28743871</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Bi LJ]] | |||
[[Category: Gao YR]] | |||
[[Category: Li DF]] | |||
[[Category: Wang DC]] | |||
Latest revision as of 09:16, 20 March 2024
Crystal structure of MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN Rv2887 complex with DNA
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