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| [[Image:1ih4.gif|left|200px]]
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| {{Structure
| | ==Multi-Conformation Crystal Structure of GGm5CGCC== |
| |PDB= 1ih4 |SIZE=350|CAPTION= <scene name='initialview01'>1ih4</scene>, resolution 1.9Å
| | <StructureSection load='1ih4' size='340' side='right'caption='[[1ih4]], [[Resolution|resolution]] 1.90Å' scene=''> |
| |SITE= | | == Structural highlights == |
| |LIGAND= <scene name='pdbligand=5CM:5-METHYL-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>
| | <table><tr><td colspan='2'>[[1ih4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IH4 FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| |GENE=
| | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr> |
| |DOMAIN=
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ih4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih4 OCA], [https://pdbe.org/1ih4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ih4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ih4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ih4 ProSAT]</span></td></tr> |
| |RELATEDENTRY=[[1ih1|1IH1]], [[1ih2|1IH2]], [[1ih3|1IH3]], [[1ih6|1IH6]]
| | </table> |
| |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ih4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih4 OCA], [http://www.ebi.ac.uk/pdbsum/1ih4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ih4 RCSB]</span>
| | __TOC__ |
| }}
| | </StructureSection> |
| | | [[Category: Large Structures]] |
| '''Multi-Conformation Crystal Structure of GGm5CGCC'''
| | [[Category: Henderson K]] |
| | | [[Category: Ho PS]] |
| | | [[Category: Vargason JM]] |
| ==Overview==
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| The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
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| ==About this Structure==
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| 1IH4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA].
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| ==Reference==
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| A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969]
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| [[Category: Protein complex]] | |
| [[Category: Henderson, K.]] | |
| [[Category: Ho, P S.]] | |
| [[Category: Vargason, J M.]] | |
| [[Category: b to a dna transition]]
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| [[Category: dna transition]]
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| [[Category: structural transition]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:42 2008''
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