5iq8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5iq8 is ON HOLD  until Paper Publication
==Crystal structure of TEM1 beta-lactamase mutant A224C/G283C disulfide==
<StructureSection load='5iq8' size='340' side='right'caption='[[5iq8]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQ8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iq8 OCA], [https://pdbe.org/5iq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iq8 RCSB], [https://www.ebi.ac.uk/pdbsum/5iq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iq8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.


Authors:  
==See Also==
 
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
Description:  
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Dmochowski IJ]]
[[Category: Roose BW]]
Retrieved from "https://proteopedia.org/5iq8"