5jcd: Difference between revisions

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'''Unreleased structure'''


The entry 5jcd is ON HOLD
==Crystal structure of OsCEBiP==
<StructureSection load='5jcd' size='340' side='right'caption='[[5jcd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jcd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa_Japonica_Group Oryza sativa Japonica Group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JCD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jcd OCA], [https://pdbe.org/5jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jcd RCSB], [https://www.ebi.ac.uk/pdbsum/5jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jcd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CEBIP_ORYSJ CEBIP_ORYSJ] Chitin elicitor-binding protein involved in the perception and transduction of chitin oligosaccharide elicitor signal for defense responses.<ref>PMID:16829581</ref> <ref>PMID:21070404</ref> <ref>PMID:22891159</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Chitin is the major component of fungal cell wall and serves as a molecular pattern that can be recognized by the receptor OsCEBiP in rice, a lysine motif (LysM) receptor-like protein (RLP), to trigger immune responses. The molecular mechanisms underlying chitin recognition remain elusive. Here we report the crystal structures of the ectodomain of OsCEBiP (OsCEBiP-ECD) in free and chitin-bound forms. The structures reveal that OsCEBiP-ECD contains three tandem LysMs followed by a novel structure fold of cysteine-rich domain. The structures showed that chitin binding induces no striking conformational changes in OsCEBiP. Structural comparison among N-acetylglucosamine (NAG) oligomer-bound LysMs revealed a highly conserved recognition mechanism, which is expected to facilitate study of other LysM-containing proteins for their NAG binding. Modeling study showed that chitin induces OsCEBiP homodimerization in a "sliding mode". Our data provide insights into rice chitin receptor-mediated immunity triggered by fungal cell wall.


Authors:  
Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP.,Liu S, Wang J, Han Z, Gong X, Zhang H, Chai J Structure. 2016 May 24. pii: S0969-2126(16)30075-2. doi:, 10.1016/j.str.2016.04.014. PMID:27238968<ref>PMID:27238968</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 5jcd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryza sativa Japonica Group]]
[[Category: Chai JJ]]
[[Category: Liu SM]]
[[Category: Wang JZ]]
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