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==Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole==
==Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole==
<StructureSection load='4ze0' size='340' side='right' caption='[[4ze0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4ze0' size='340' side='right'caption='[[4ze0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ze0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZE0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZE0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ze0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_YJM789 Saccharomyces cerevisiae YJM789]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZE0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VOR:VORICONAZOLE'>VOR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lxj|4lxj]], [[4wmz|4wmz]], [[4k0f|4k0f]], [[4zdy|4zdy]], [[4zdz|4zdz]], [[4ze1|4ze1]], [[4ze2|4ze2]], [[4ze3|4ze3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VOR:VORICONAZOLE'>VOR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ze0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ze0 OCA], [http://pdbe.org/4ze0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ze0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ze0 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ze0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ze0 OCA], [https://pdbe.org/4ze0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ze0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ze0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ze0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A6ZSR0_YEAS7 A6ZSR0_YEAS7]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ze0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ze0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Keniya, M V]]
[[Category: Large Structures]]
[[Category: Monk, B C]]
[[Category: Saccharomyces cerevisiae YJM789]]
[[Category: Sagatova, A]]
[[Category: Keniya MV]]
[[Category: Tyndall, J D.A]]
[[Category: Monk BC]]
[[Category: Wilson, R]]
[[Category: Sagatova A]]
[[Category: Cyp51]]
[[Category: Tyndall JDA]]
[[Category: Oxidoreductase-oxidoreducatse inhibitor complex]]
[[Category: Wilson R]]
[[Category: Resistance mutation]]
[[Category: Y140f]]

Latest revision as of 12:02, 13 August 2026

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole

4ze0, resolution 2.20Å

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