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==Crystal structure of mouse hepatitis virus strain DVIM Hemagglutinin-Esterase==
==Crystal structure of mouse hepatitis virus strain DVIM Hemagglutinin-Esterase==
<StructureSection load='5jif' size='340' side='right' caption='[[5jif]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5jif' size='340' side='right'caption='[[5jif]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jif]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIF FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jif]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_coronavirus_strain_DVIM Murine coronavirus strain DVIM]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JIF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sialate_O-acetylesterase Sialate O-acetylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.53 3.1.1.53] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jif OCA], [http://pdbe.org/5jif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jif RCSB], [http://www.ebi.ac.uk/pdbsum/5jif PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jif OCA], [https://pdbe.org/5jif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jif RCSB], [https://www.ebi.ac.uk/pdbsum/5jif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jif ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HEMA_CVMDV HEMA_CVMDV]] Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system.  
[https://www.uniprot.org/uniprot/HEMA_CVMDV HEMA_CVMDV] Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jif" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jif" style="background-color:#fffaf0;"></div>
==See Also==
*[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Sialate O-acetylesterase]]
[[Category: Large Structures]]
[[Category: Bakkers, M J.G]]
[[Category: Murine coronavirus strain DVIM]]
[[Category: Feitsma, L J]]
[[Category: Bakkers MJG]]
[[Category: Groot, R J.de]]
[[Category: Feitsma LJ]]
[[Category: Huizinga, E G]]
[[Category: Huizinga EG]]
[[Category: Zeng, Q H]]
[[Category: Zeng QH]]
[[Category: Coronavirus]]
[[Category: De Groot RJ]]
[[Category: Esterase]]
[[Category: Hemagglutin]]
[[Category: Hepatitis virus]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/5jif"