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==N-terminal dimerization domain of H-NS in complex with Hha (Salmonella Typhimurium)==
==N-terminal dimerization domain of H-NS in complex with Hha (Salmonella Typhimurium)==
<StructureSection load='4icg' size='340' side='right' caption='[[4icg]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
<StructureSection load='4icg' size='340' side='right'caption='[[4icg]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4icg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saltu Saltu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ICG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ICG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4icg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ICG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ICG FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9217&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hns, hnsA, osmZ, STM1751, STMUK_1724 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=990282 SALTU]), hha, STM0473, STMUK_0480 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=990282 SALTU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4icg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4icg OCA], [http://pdbe.org/4icg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4icg RCSB], [http://www.ebi.ac.uk/pdbsum/4icg PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4icg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4icg OCA], [https://pdbe.org/4icg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4icg RCSB], [https://www.ebi.ac.uk/pdbsum/4icg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4icg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HNS_SALTY HNS_SALTY]] H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. It plays a role in the thermal control of pili production. It is subject to transcriptional auto-repression. It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (By similarity).  
[https://www.uniprot.org/uniprot/HNS_SALTY HNS_SALTY] H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. It plays a role in the thermal control of pili production. It is subject to transcriptional auto-repression. It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Saltu]]
[[Category: Large Structures]]
[[Category: Ali, S S]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Howell, P L]]
[[Category: Ali SS]]
[[Category: Navarre, W W]]
[[Category: Howell PL]]
[[Category: Robinson, H]]
[[Category: Navarre WW]]
[[Category: Stevenson, J]]
[[Category: Robinson H]]
[[Category: Whitney, J C]]
[[Category: Stevenson J]]
[[Category: Dna binding protein]]
[[Category: Whitney JC]]
[[Category: Hha]]
Retrieved from "https://proteopedia.org/4icg"