5fey: Difference between revisions

<StructureSection load='5fey' size='340' side='right'caption='[[5fey]], [[Resolution|resolution]] 2.23&Aring;' scene=''>

<table><tr><td colspan='2'>[[5fey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FEY FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fey OCA], [https://pdbe.org/5fey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fey RCSB], [https://www.ebi.ac.uk/pdbsum/5fey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fey ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[https://omim.org/entry/254110 254110]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref>  Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[https://omim.org/entry/209900 209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>  

[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Esposito D]]

[[Category: Koliopoulos MG]]

[[Category: Rittinger K]]