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==Crystal structure of the Scm-SAM and Sfmbt-SAM heterodimer==
==Crystal structure of the Scm-SAM and Sfmbt-SAM heterodimer==
<StructureSection load='5j8y' size='340' side='right' caption='[[5j8y]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='5j8y' size='340' side='right'caption='[[5j8y]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5j8y]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[5j8y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J8Y FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8y OCA], [http://pdbe.org/5j8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8y RCSB], [http://www.ebi.ac.uk/pdbsum/5j8y PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8y OCA], [https://pdbe.org/5j8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j8y RCSB], [https://www.ebi.ac.uk/pdbsum/5j8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SCM_DROME SCM_DROME]] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.<ref>PMID:15280237</ref> [UniProtKB:Q9W3C1] [[http://www.uniprot.org/uniprot/SMBT_DROME SMBT_DROME]] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:16618800</ref> 
[https://www.uniprot.org/uniprot/SCM_DROME SCM_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.<ref>PMID:15280237</ref> [UniProtKB:Q9W3C1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5j8y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j8y" style="background-color:#fffaf0;"></div>
==See Also==
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Benda, C]]
[[Category: Drosophila melanogaster]]
[[Category: Frey, F]]
[[Category: Large Structures]]
[[Category: Mueller, J]]
[[Category: Benda C]]
[[Category: Drosophila]]
[[Category: Frey F]]
[[Category: Nuclear protein]]
[[Category: Mueller J]]
[[Category: Prc1 phorc sam domain polycom response element]]
[[Category: Signaling protein]]
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