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==Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development==
==Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development==
<StructureSection load='5j69' size='340' side='right' caption='[[5j69]], [[Resolution|resolution]] 3.63&Aring;' scene=''>
<StructureSection load='5j69' size='340' side='right'caption='[[5j69]], [[Resolution|resolution]] 3.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5j69]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J69 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5j69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J69 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.63&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j69 OCA], [http://pdbe.org/5j69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j69 RCSB], [http://www.ebi.ac.uk/pdbsum/5j69 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j69 OCA], [https://pdbe.org/5j69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j69 RCSB], [https://www.ebi.ac.uk/pdbsum/5j69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j69 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASTN2_HUMAN ASTN2_HUMAN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The vertebrate-specific proteins astrotactin-1 and 2 (ASTN-1 and ASTN-2) are integral membrane perforin-like proteins known to play critical roles in neurodevelopment, while ASTN-2 has been linked to the planar cell polarity pathway in hair cells. Genetic variations associated with them are linked to a variety of neurodevelopmental disorders and other neurological pathologies, including an advanced onset of Alzheimer's disease. Here we present the structure of the majority endosomal region of ASTN-2, showing it to consist of a unique combination of polypeptide folds: a perforin-like domain, a minimal epidermal growth factor-like module, a unique form of fibronectin type III domain and an annexin-like domain. The perforin-like domain differs from that of other members of the membrane attack complex-perforin (MACPF) protein family in ways that suggest ASTN-2 does not form pores. Structural and biophysical data show that ASTN-2 (but not ASTN-1) binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, and yet shares no sequence homology with it. Overall, our structure provides the first atomic-resolution description of a MACPF protein involved in development, while highlighting distinctive features of ASTN-2 responsible for its activity.
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.,Ni T, Harlos K, Gilbert R Open Biol. 2016 May;6(5). pii: 160053. doi: 10.1098/rsob.160053. Epub 2016 May 4. PMID:27249642<ref>PMID:27249642</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5j69" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gilbert, R J.C]]
[[Category: Homo sapiens]]
[[Category: Harlos, K]]
[[Category: Large Structures]]
[[Category: Ni, T]]
[[Category: Gilbert RJC]]
[[Category: Annexin-like domain]]
[[Category: Harlos K]]
[[Category: Fibronectin]]
[[Category: Ni T]]
[[Category: Macpf domain]]
[[Category: Membrane protein]]
[[Category: Neural guidance]]
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