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| | | #REDIRECT [[5wo3]] This PDB entry is obsolete and replaced by 5wo3 |
| ==Chaperone Spy bound to Im7 (Im7 un-modeled)==
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| <StructureSection load='5ioa' size='340' side='right' caption='[[5ioa]], [[Resolution|resolution]] 1.87Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[5ioa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IOA FirstGlance]. <br>
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| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ina|5ina]], [[5ioe|5ioe]], [[5iog|5iog]]</td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ioa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ioa OCA], [http://pdbe.org/5ioa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ioa RCSB], [http://www.ebi.ac.uk/pdbsum/5ioa PDBsum]</span></td></tr>
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| </table>
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| == Function ==
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| [[http://www.uniprot.org/uniprot/SPY_ECOLI SPY_ECOLI]] An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region of its convex inner surface (PubMed:21317898, PubMed:24497545). Substrate protein folds while it is bound to chaperone (PubMed:26619265). Increasing Spy flexibility increases its substrate affinity and overall chaperone activity (shown for 3 different substrates) (PubMed:24497545). Protects proteins in vitro against tannin inactivation; tannins have antimicrobial activity (PubMed:21317898). Overexpression enhances the stability of otherwise unstable periplasmic proteins (PubMed:21317898).<ref>PMID:21317898</ref> <ref>PMID:24497545</ref> <ref>PMID:26619265</ref>
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Bardwell, J C.A]]
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| [[Category: Horowitz, S]]
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| [[Category: Koldewey, P]]
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| [[Category: Martin, R]]
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| [[Category: Chaperone]]
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This PDB entry is obsolete and replaced by 5wo3
