Nucleoside diphosphate kinase: Difference between revisions

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<StructureSection load='1ucn' size='450' side='right' caption='Human nucleoside diphosphate kinase complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry [[1ucn]])' scene='48/487511/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Human nucleoside diphosphate kinase complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry [[1ucn]])' scene='48/487511/Cv/1'>


== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==


The biological assembly of Human nucleoside diphosphate kinase is <scene name='48/487511/Cv/2'>homohexamer</scene>. The NDK-adenine structure shows the <scene name='48/487511/Cv/5'>two reaction products: ADP and phosphate</scene><ref>PMID:12972261</ref>. <scene name='48/487511/Cv/6'>Ca coordination site</scene>. Water molecules shown as red spheres.
The biological assembly of Human nucleoside diphosphate kinase is <scene name='48/487511/Cv/7'>homohexamer</scene>. The NDK-adenine structure shows the <scene name='48/487511/Cv/8'>two reaction products: ADP and phosphate</scene><ref>PMID:12972261</ref>. Water molecules are shown as red spheres. <scene name='48/487511/Cv/9'>Ca coordination site</scene>.  
</StructureSection>


==3D structures of nucleoside diphosphate kinase==
==3D structures of nucleoside diphosphate kinase==
[[Nucleoside diphosphate kinase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*'''Nucleoside diphosphate kinase'''
 
**[[1ndk]], [[1npk]], [[1s5z]] – DdNDK – ''Dictyostelium discoideum''<BR />
**[[1nlk]], [[1nsp]] - DdNDK with phosphohistidine intermediate<BR />
**[[1leo]], [[1ncl]], [[1hlw]], [[1hhq]], [[1pae]], [[4c6a]] - DdNDK (mutant) <BR />
**[[2nck]] – MxNDK – ''Myxococcus xanthus''<BR />
**[[1ndl]] – DmNDK – ''Drosophila melanogaster''<BR />
**[[1nsq]] - DmNDK with phosphohistidine intermediate<BR />
**[[1nsk]], [[1jxv]], [[3l7u]], [[4eno]] - hNDK A – human<BR />
**[[1ehw]] - hNDK 4 (mutant) <BR />
**[[3bbc]] - hNDK B (mutant)<br />
**[[1k44]], [[4anc]] – MtNDK – ''Mycobacterium tuberculosis''<BR />
**[[4and]], [[4ane]] - MtNDK (mutant)<br />
**[[1nb2]] - NDK - ''Virgibacillus halodenitrificans''<BR />
**[[1xiq]] - NDK A – ''Plasmodium falciparum''<BR />
**[[1w7w]] - NDK – pea<BR />
**[[1u8w]] - AtNDK I –'' Arabidopsis thaliana''<BR />
**[[1s57]] - AtNDK II<BR />
**[[1pku]] - NDK I – rice<BR />
**[[1wkj]] - TtNDK – ''Thermus thermophilus''<BR />
**[[1xqi]] - NDK (mutant) – ''Pyrobaculum aerophilum''<BR />
**[[2az1]] - HsNDK – ''Halobacterium salinarum''<BR />
**[[2hur]] - NDK – ''Escherichia coli''<BR />
**[[3b54]] - NDK – yeast<BR />
**[[2vu5]] - NDK – ''Bacillus anthracis''<BR />
**[[2zua]] - NDK – ''Haloarcula quadrata''<BR />
**[[3mpd]] - NDK – ''Encephalitozoon cuniculi''<BR />
**[[3pj9]] - NDK – ''Campylobacter jejuni''<BR />
**[[3r9l]] - NDK – ''Giardia lamblia''<BR />
**[[3ngr]], [[3ngs]] - LmNDK – ''Leishmania major''<BR />
**[[3prv]] - NDK – ''Trypanosoma cruzi''<BR />
**[[3q83]] - SaNDK – ''Staphylococcus aureus''<BR />
**[[4di6]] - BbNDK – ''Borrelia burgdorferi''<BR />
**[[3ztq]], [[3zto]], [[3ztp]], [[3ztr]], [[3zts]] - NDK – ''Aquifex aeolicus''<BR />
**[[4dut]] - BtNDK – ''Burkholderia thailandensis''<br />
**[[2cwk]] - PhNDK – ''Pyrococcus horikoshii''<br />
**[[3vgs]], [[3vgt]] - HaNDK – ''Halomonas''<br />
**[[3vgu]], [[3vgv]] - HaNDK (mutant)<br />
**[[3vvt]] - NDK – reconstructed archaeal ancestral<br />
**[[3vvu]] - NDK – reconstructed bacterial ancestral<br />
**[[4f36]] – TbNDK – ''Trypanosoma brucei''<br />
 
*NDK complex with adenine derivative
 
**[[1ndp]], [[1kdn]], [[2bef]] – DdNDK + ADP<BR />
**[[1b4s]] - DdNDK (mutant) + ADP<BR />
**[[1bux]], [[1hiy]] - DdNDK + ADP derivative<br />
**[[1nlk]] - MxNDK + ADP<BR />
**[[2hvd]] - hNDK + ADP<BR />
**[[1ucn]], [[2hve]] - hNDK (mutant) + ADP<BR />
**[[1zs6]] - hNDK 3 + ADP<BR />
**[[2dxd]] - PhNDK + ATP analog <BR />
**[[2dy9]], [[2dya]] - PhNDK + ADP<BR />
**[[3ngt]] - LmNDK + AMP<BR />
**[[3ngu]] - LmNDK + ADP<BR />
**[[3q8u]], [[3q8y]] - SaNDK + ADP<BR />
**[[4dz6]] - BbNDK + ADP<BR />
**[[1wkl]] - TtNDK + ADP + ATP<br />
**[[4ek2]] - BtNDK + AMP derivative<br />
**[[4hr2]] - BtNDK + ADP<br />
 
*NDK complex with thymidine derivative
 
**[[1f3f]] - DdNDK (mutant) + TDP derivative + TTP derivative<br />
**[[1lwx]] - DdNDK (mutant) + azido-TDP<BR />
**[[1f6t]] - DdNDK + TDP derivative<br />
**[[1mn7]] - DdNDK (mutant) + TTP derivative<br />
**[[1ndc]] - DdNDK + TDP<BR />
**[[3ddi]] - ApNDK (mutant) + TDP – ''Acanthamoeba polyphaga''<BR />
**[[3em1]], [[3evw]], [[3fbc]], [[3fbf]], [[3g2x]], [[3evo]] - ApNDK (mutant) + TDP derivative<br />
 
*NDK complex with cytosine derivative
 
**[[1nhk]] - MxNDK + CMP<BR />
**[[2az3]] - HsNDK + CDP<BR />
**[[3ee3]] - ApNDK + CDP<BR />
**[[3etm]], [[3gpa]], [[3fc9]] - ApNDK (mutant) + CDP<BR />
**[[3evm]] - ApNDK (mutant) + CDP derivative<br />
**[[3q89]] - SaNDK + CDP<BR />
**[[4fkx]] - TbNDK + CDP<br />
 
*NDK complex with guanine derivative
 
**[[1nue]] , [[3bbf]] - hNDK + GDP<BR />
**[[1s59]] - AtNDK + GDP derivative + GTP derivative<br />
**[[3bbb]] - hNDK B + GMP derivative + AMP derivative<br />
**[[1wkk]] - TtNDK + GDP<BR />
**[[2dxe]] - PhNDK + GDP<BR />
**[[2dxf]] - PhNDK + GTP analog<BR />
**[[3gp9]] - ApNDK + GDP<BR />
**[[3b6b]] - ApNDK + GDP derivative<br />
**[[3fbe]], [[3dkd]], [[3ejm]] - ApNDK (mutant) + GDP<BR />
**[[3emt]], [[3ena]] - ApNDK (mutant) + GDP derivative<br />
**[[3q86]] - SaNDK + GTP
 
*NDK complex with uridine derivative
 
**[[1b99]] - DdNDK + UDP derivative<br />
**[[3eic]] - ApNDK + UDP<BR />
**[[3elh]] - ApNDK + UDP derivative<br />
**[[3fbb]], [[3fcv]] - ApNDK (mutant) + UDP derivative<br />
**[[3fcw]] - ApNDK (mutant) + UDP<BR />
**[[3q8v]] - SaNDK + UDP<BR />
**[[4f4a]] - TbNDK + UDP<br />
 
*NDK complex with antiviral drug


**[[1mn9]], [[3fkb]] - DdNDK (mutant) + antiviral drug
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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