Fructokinase: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' scene='48/484862/Cv/2' caption='Fructokinase with ADP and Fructose bound in the active site [[3lm9]]'> | ||
== Function == | == Function == | ||
'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>. | '''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>. | ||
*<scene name='48/484862/Cv/6'>Fructokinase with ADP and fructose bound in the active site</scene> ([[3lm9]]). Water molecules shown as red spheres. | |||
== Relevance == | == Relevance == | ||
Inhibitors of FRK C may block sugar-associated metabolic syndromes. | Inhibitors of FRK C may block sugar-associated metabolic syndromes<ref>PMID:23439477</ref>. | ||
== Disease == | == Disease == | ||
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[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br /> | [[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br /> | ||
[[3c8u]] – FRK – ''Silicibacter''<br /> | [[3c8u]] – FRK – ''Silicibacter''<br /> | ||
[[5ey7]] – VcFRK – ''Vibrio cholerae''<br /> | |||
[[5f11]] – VcFRK + fructose <br /> | |||
[[5f0z]], [[5ygg]] – VcFRK + fructose + ADP<br /> | |||
[[5eyn]] – VcFRK + fructose + ADP + BeF3<br /> | |||
[[7cf8]], [[7cfa]] – FRK – ''Mycobacterium marinum''<br /> | |||
[[4u7x]] – BaFRK – ''Brucella abortus''<br /> | |||
[[4wjm]] – BaFRK + AMPPNP<br /> | |||
For Hepatic fructokinase see [[Ketohexokinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 06:54, 7 July 2025
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3D structures of fructokinase
Updated on 07-July-2025
3lm9 – FRK – Bacterioides thetaiotamicron
3ljs – XfFRK – Xylella fastidiosa
3hj6 – FRK – Halothermothrix orenii
3lki – XfFRK + ATP
3lm9 - BsFRK + ATP + fructose – Bacillus subtilis
3ohr - BsFRK + ADP
2v78, 2var – FRK – Sulfolobus solfataricus
3c8u – FRK – Silicibacter
5ey7 – VcFRK – Vibrio cholerae
5f11 – VcFRK + fructose
5f0z, 5ygg – VcFRK + fructose + ADP
5eyn – VcFRK + fructose + ADP + BeF3
7cf8, 7cfa – FRK – Mycobacterium marinum
4u7x – BaFRK – Brucella abortus
4wjm – BaFRK + AMPPNP
For Hepatic fructokinase see Ketohexokinase
