5ick: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5ick is ~~ON HOLD until sometime in~~ the ~~future~~

==A unique binding model of FXR LBD with feroline==

== Structural highlights ==

<table><tr><td colspan='2'>[[5ick]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICK OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5ICK FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEZ:(1S,2S,3Z,5S,8Z)-5-HYDROXY-5,9-DIMETHYL-2-(PROPAN-2-YL)CYCLODECA-3,8-DIEN-1-YL+4-HYDROXYBENZOATE'>FEZ</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5ick FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ick OCA], [https://pdbe.org/5ick PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ick RCSB], [https://www.ebi.ac.uk/pdbsum/5ick PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ick ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>

~~Authors: Lu, Y., Li, Y.~~

==See Also==

*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]

~~Description~~: ~~A unique binding model of FXR LBD with feroline~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: Li, Y]]

__TOC__

[[Category: Lu, Y]]

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Li Y]]

[[Category: Lu Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ick is ON HOLD  until sometime in the future
+==A unique binding model of FXR LBD with feroline==
+<StructureSection load='5ick' size='340' side='right'caption='[[5ick]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ick]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ICK FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEZ:(1S,2S,3Z,5S,8Z)-5-HYDROXY-5,9-DIMETHYL-2-(PROPAN-2-YL)CYCLODECA-3,8-DIEN-1-YL+4-HYDROXYBENZOATE'>FEZ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ick FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ick OCA], [https://pdbe.org/5ick PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ick RCSB], [https://www.ebi.ac.uk/pdbsum/5ick PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ick ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
-Authors: Lu, Y., Li, Y.
+==See Also==
+*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
-Description: A unique binding model of FXR LBD with feroline
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Li, Y]]
+__TOC__
-[[Category: Lu, Y]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li Y]]
+[[Category: Lu Y]]