5k6j: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5k6j is ~~ON HOLD until Paper Publication~~

==Human Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor==

== Structural highlights ==

<table><tr><td colspan='2'>[[5k6j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5K6J FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6QQ:6-[[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl]oxy]-5-chloranyl-2-(4-oxidanylidenepentoxy)pyridine-3-carbonitrile'>6QQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5k6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6j OCA], [https://pdbe.org/5k6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k6j RCSB], [https://www.ebi.ac.uk/pdbsum/5k6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6j ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>

~~Authors~~:

==See Also==

*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Rock FL]]

[[Category: Sullivan D]]

[[Category: Zhou Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5k6j is ON HOLD  until Paper Publication
+==Human Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor==
+<StructureSection load='5k6j' size='340' side='right'caption='[[5k6j]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5k6j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K6J FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6QQ:6-[[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl]oxy]-5-chloranyl-2-(4-oxidanylidenepentoxy)pyridine-3-carbonitrile'>6QQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6j OCA], [https://pdbe.org/5k6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k6j RCSB], [https://www.ebi.ac.uk/pdbsum/5k6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
-Authors:
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Rock FL]]
+[[Category: Sullivan D]]
+[[Category: Zhou Y]]