5kch: Difference between revisions
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New page: '''Unreleased structure''' The entry 5kch is ON HOLD Authors: Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Arrowsmith, C.H., Edwards, ... |
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==SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy into weak electron density== | |||
<StructureSection load='5kch' size='340' side='right'caption='[[5kch]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5kch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KCH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RN:4-(PYRIDIN-2-YLMETHYLAMINO)PHENOL'>6RN</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kch OCA], [https://pdbe.org/5kch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kch RCSB], [https://www.ebi.ac.uk/pdbsum/5kch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kch ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref> | |||
==See Also== | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Dobrovetsky | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Brandao-Neto J]] | ||
[[Category: Santhakumar | [[Category: Brown PJ]] | ||
[[Category: | [[Category: Collins P]] | ||
[[Category: | [[Category: Dobrovetsky E]] | ||
[[Category: | [[Category: Douangamath A]] | ||
[[Category: Edwards AM]] | |||
[[Category: Harding RJ]] | |||
[[Category: Mader P]] | |||
[[Category: Pearce N]] | |||
[[Category: Santhakumar V]] | |||
[[Category: Schapira M]] | |||
[[Category: Tempel W]] | |||
[[Category: Walker JR]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 09:58, 27 September 2023
SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy into weak electron density
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