5l7u: Difference between revisions
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New page: '''Unreleased structure''' The entry 5l7u is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of BvGH123 with bound GalNAc== | |||
<StructureSection load='5l7u' size='340' side='right'caption='[[5l7u]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l7u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phocaeicola_vulgatus_ATCC_8482 Phocaeicola vulgatus ATCC 8482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L7U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7u OCA], [https://pdbe.org/5l7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l7u RCSB], [https://www.ebi.ac.uk/pdbsum/5l7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7u ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A6L2E5_PHOV8 A6L2E5_PHOV8] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-beta-galactosaminidase that acts with retention of stereochemistry, and, through a 3-D structure in complex with Gal-thiazoline, provide evidence in support of a neighbouring group participation mechanism. | |||
Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-beta-galactosaminidase that uses neighbouring group participation.,Roth C, Petricevic M, John A, Goddard-Borger ED, Davies GJ, Williams SJ Chem Commun (Camb). 2016 Sep 25;52(74):11096-9. doi: 10.1039/c6cc04649e. Epub, 2016 Aug 22. PMID:27546776<ref>PMID:27546776</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5l7u" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Phocaeicola vulgatus ATCC 8482]] | |||
[[Category: Davies GJ]] | |||
[[Category: Goddard-Borger ED]] | |||
[[Category: John A]] | |||
[[Category: Petricevic M]] | |||
[[Category: Roth C]] | |||
[[Category: Williams SJ]] | |||
Latest revision as of 16:10, 4 October 2023
Crystal structure of BvGH123 with bound GalNAc
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