5ev9: Difference between revisions
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==Crystal structure of the human BRPF1 bromodomain in complex with SEED15== | ==Crystal structure of the human BRPF1 bromodomain in complex with SEED15== | ||
<StructureSection load='5ev9' size='340' side='right' caption='[[5ev9]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='5ev9' size='340' side='right'caption='[[5ev9]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ev9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV9 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5ev9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EV9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5SB:~{N}-[5-(1~{H}-PYRAZOL-4-YL)QUINOLIN-8-YL]ETHANAMIDE'>5SB</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5SB:~{N}-[5-(1~{H}-PYRAZOL-4-YL)QUINOLIN-8-YL]ETHANAMIDE'>5SB</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ev9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev9 OCA], [https://pdbe.org/5ev9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ev9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ev9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5ev9" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5ev9" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Peregrin|Peregrin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Caflisch A]] | ||
[[Category: | [[Category: Zhu J]] | ||
Latest revision as of 11:33, 10 January 2024
Crystal structure of the human BRPF1 bromodomain in complex with SEED15
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