5khu: Difference between revisions
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New page: '''Unreleased structure''' The entry 5khu is ON HOLD Authors: Yamaguchi, M., VanderLinden, R., Dube, P., Stark, H., Schulman, B. Description: APC/C delta_apc15 CDC20 MMC(in) [[Category... |
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==Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution== | |||
<SX load='5khu' size='340' side='right' viewer='molstar' caption='[[5khu]], [[Resolution|resolution]] 4.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5khu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KHU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5khu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khu OCA], [https://pdbe.org/5khu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5khu RCSB], [https://www.ebi.ac.uk/pdbsum/5khu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5khu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/APC16_HUMAN APC16_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:20360068</ref> | |||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Dube | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Yamaguchi | [[Category: Dube P]] | ||
[[Category: Schulman B]] | |||
[[Category: Stark H]] | |||
[[Category: VanderLinden R]] | |||
[[Category: Yamaguchi M]] | |||
Latest revision as of 12:40, 6 March 2024
Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution
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