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==Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+==
==Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+==
<StructureSection load='5esd' size='340' side='right' caption='[[5esd]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5esd' size='340' side='right'caption='[[5esd]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5esd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5esd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ESD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5erx|5erx]], [[5ery|5ery]], [[5esu|5esu]], [[5eso|5eso]], [[5ess|5ess]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid_synthase 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.9 2.2.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esd OCA], [https://pdbe.org/5esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5esd RCSB], [https://www.ebi.ac.uk/pdbsum/5esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5esd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esd OCA], [http://pdbe.org/5esd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esd RCSB], [http://www.ebi.ac.uk/pdbsum/5esd PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MEND_MYCTU MEND_MYCTU]] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).  
[https://www.uniprot.org/uniprot/MEND_MYCTU MEND_MYCTU] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase]]
[[Category: Large Structures]]
[[Category: Baker, E N]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bashiri, G]]
[[Category: Baker EN]]
[[Category: Bulloch, E M.M]]
[[Category: Bashiri G]]
[[Category: Jirgis, E N.M]]
[[Category: Bulloch EMM]]
[[Category: Johnston, J M]]
[[Category: Jirgis ENM]]
[[Category: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase]]
[[Category: Johnston JM]]
[[Category: Hydrolase]]
[[Category: Menaquinone biosynthesis]]
[[Category: Mend]]
[[Category: Pyruvate oxidase family]]
[[Category: Thiamin-diphosphate dependent enzyme]]
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