4zs8: Difference between revisions

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==Crystal structure of ligand-free, full length DasR==
==Crystal structure of ligand-free, full length DasR==
<StructureSection load='4zs8' size='340' side='right' caption='[[4zs8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4zs8' size='340' side='right'caption='[[4zs8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zs8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZS8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zs8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZS8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zs8 OCA], [http://pdbe.org/4zs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zs8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zs8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zs8 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zs8 OCA], [https://pdbe.org/4zs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zs8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zs8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DASR_STRCO DASR_STRCO]] Global regulator that is part of the nutrient-sensing system. In the absence of N-acetylglucosamine 6-P, represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3'.<ref>PMID:15247334</ref> <ref>PMID:16925557</ref>
[https://www.uniprot.org/uniprot/DASR_STRCO DASR_STRCO] Global regulator that is part of the nutrient-sensing system. In the absence of N-acetylglucosamine 6-P, represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3'.<ref>PMID:15247334</ref> <ref>PMID:16925557</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fillenberg, S B]]
[[Category: Large Structures]]
[[Category: Muller, Y A]]
[[Category: Fillenberg SB]]
[[Category: Bacterial transcription regulation]]
[[Category: Muller YA]]
[[Category: Gntr/hutc family]]
[[Category: Ligand-free]]
[[Category: Master regulator]]
[[Category: N-acetylglucosamine utilization]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription factor]]
[[Category: Winged helix-turn-helix motif]]