1k0k: Difference between revisions

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[[Image:1k0k.gif|left|200px]]


{{Structure
==Yeast Profilin, Cubic Crystal Form==
|PDB= 1k0k |SIZE=350|CAPTION= <scene name='initialview01'>1k0k</scene>, resolution 2.35&Aring;
<StructureSection load='1k0k' size='340' side='right'caption='[[1k0k]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
<table><tr><td colspan='2'>[[1k0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0K FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0k OCA], [https://pdbe.org/1k0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0k RCSB], [https://www.ebi.ac.uk/pdbsum/1k0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0k ProSAT]</span></td></tr>
|RELATEDENTRY=[[1ypr|1YPR]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0k OCA], [http://www.ebi.ac.uk/pdbsum/1k0k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k0k RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PROF_YEAST PROF_YEAST] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0k ConSurf].
<div style="clear:both"></div>


'''Yeast Profilin, Cubic Crystal Form'''
==See Also==
 
*[[Profilin 3D Structures|Profilin 3D Structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1K0K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0K OCA].
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Almo SC]]
[[Category: Almo, S C.]]
[[Category: Fedorov AA]]
[[Category: Fedorov, A A.]]
[[Category: Vorobiev S]]
[[Category: Vorobiev, S.]]
[[Category: actin-binding protein]]
[[Category: pip2 binding protein]]
[[Category: poly-l-proline binding protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:40 2008''
Retrieved from "https://proteopedia.org/1k0k"