2na8: Difference between revisions

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==Transmembrane Structure of the Cytokine Receptor Common Subunit beta==
==Transmembrane Structure of the Cytokine Receptor Common Subunit beta==
<StructureSection load='2na8' size='340' side='right' caption='[[2na8]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
<StructureSection load='2na8' size='340' side='right'caption='[[2na8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2na8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NA8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2na8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA8 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2na8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na8 OCA], [http://pdbe.org/2na8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2na8 RCSB], [http://www.ebi.ac.uk/pdbsum/2na8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2na8 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na8 OCA], [https://pdbe.org/2na8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na8 RCSB], [https://www.ebi.ac.uk/pdbsum/2na8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na8 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[http://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>
[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[https://omim.org/entry/614370 614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.  
[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: An, W]]
[[Category: Homo sapiens]]
[[Category: Ginsberg, M H]]
[[Category: Large Structures]]
[[Category: Schmidt, T]]
[[Category: An W]]
[[Category: Situ, A J]]
[[Category: Ginsberg MH]]
[[Category: Ulmer, T S]]
[[Category: Schmidt T]]
[[Category: Ye, F]]
[[Category: Situ AJ]]
[[Category: Membrane protein]]
[[Category: Ulmer TS]]
[[Category: Transmembrane helix]]
[[Category: Ye F]]