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[[Image:1k47.gif|left|200px]]


{{Structure
==Crystal Structure of the Streptococcus pneumoniae Phosphomevalonate Kinase (PMK)==
|PDB= 1k47 |SIZE=350|CAPTION= <scene name='initialview01'>1k47</scene>, resolution 2.42&Aring;
<StructureSection load='1k47' size='340' side='right'caption='[[1k47]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
<table><tr><td colspan='2'>[[1k47]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K47 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphomevalonate_kinase Phosphomevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.2 2.7.4.2] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
|GENE= mvaK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1577 ERG12]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k47 OCA], [https://pdbe.org/1k47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k47 RCSB], [https://www.ebi.ac.uk/pdbsum/1k47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k47 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1k47 TOPSAN]</span></td></tr>
|RELATEDENTRY=[[1fi4|1FI4]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k47 OCA], [http://www.ebi.ac.uk/pdbsum/1k47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k47 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q8DR49_STRR6 Q8DR49_STRR6]  
 
== Evolutionary Conservation ==
'''Crystal Structure of the Streptococcus pneumoniae Phosphomevalonate Kinase (PMK)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/1k47_consurf.spt"</scriptWhenChecked>
1K47 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K47 OCA].
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily., Romanowski MJ, Bonanno JB, Burley SK, Proteins. 2002 Jun 1;47(4):568-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12001237 12001237]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k47 ConSurf].
[[Category: Phosphomevalonate kinase]]
<div style="clear:both"></div>
[[Category: Single protein]]
__TOC__
[[Category: Streptococcus pneumoniae]]
</StructureSection>
[[Category: Bonanno, J B.]]
[[Category: Large Structures]]
[[Category: Burley, S K.]]
[[Category: Streptococcus pneumoniae R6]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Bonanno JB]]
[[Category: Romanowski, M J.]]
[[Category: Burley SK]]
[[Category: alpha/beta single domain belonging to the ghmp kinase superfamily]]
[[Category: Romanowski MJ]]
[[Category: mvak2]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:11 2008''
Retrieved from "https://proteopedia.org/1k47"