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[[Image:1k6r.jpg|left|200px]]


{{Structure
==STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH MOXALACTAM==
|PDB= 1k6r |SIZE=350|CAPTION= <scene name='initialview01'>1k6r</scene>, resolution 2.30&Aring;
<StructureSection load='1k6r' size='340' side='right'caption='[[1k6r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MXL:MOXALACTAM'>MXL</scene>
<table><tr><td colspan='2'>[[1k6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6R FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= plasmid pMON234 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MX1:(2R)-2-((R)-CARBOXY{[CARBOXY(4-HYDROXYPHENYL)ACETYL]AMINO}METHOXYMETHYL)-5-METHYLENE-5,6-DIHYDRO-2H-1,3-OXAZINE-4-CARBOXYLIC+ACID'>MX1</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6r OCA], [https://pdbe.org/1k6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6r RCSB], [https://www.ebi.ac.uk/pdbsum/1k6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6r ProSAT]</span></td></tr>
|RELATEDENTRY=[[1k4e|1K4E]], [[1k4f|1K4F]], [[1k6s|1K6S]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6r OCA], [http://www.ebi.ac.uk/pdbsum/1k6r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k6r RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/BLO10_PSEAI BLO10_PSEAI] Hydrolyzes both carbenicillin and oxacillin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6r ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH MOXALACTAM'''
==See Also==
 
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1K6R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6R OCA].
[[Category: Large Structures]]
[[Category: Beta-lactamase]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Charlier P]]
[[Category: Charlier, P.]]
[[Category: Fonze E]]
[[Category: Fonze, E.]]
[[Category: Frere JM]]
[[Category: Frere, J M.]]
[[Category: Kerff F]]
[[Category: Kerff, F.]]
[[Category: Sauvage E]]
[[Category: Sauvage, E.]]
[[Category: beta-lactamase]]
[[Category: class d]]
[[Category: hydrolase]]
[[Category: moxalactam]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:20 2008''

Latest revision as of 04:39, 17 October 2024

STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH MOXALACTAM

1k6r, resolution 2.30Å

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