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[[Image:1kaw.jpg|left|200px]]


{{Structure
==STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)==
|PDB= 1kaw |SIZE=350|CAPTION= <scene name='initialview01'>1kaw</scene>, resolution 2.9&Aring;
<StructureSection load='1kaw' size='340' side='right'caption='[[1kaw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1kaw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KAW FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kaw OCA], [https://pdbe.org/1kaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kaw RCSB], [https://www.ebi.ac.uk/pdbsum/1kaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kaw ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kaw OCA], [http://www.ebi.ac.uk/pdbsum/1kaw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kaw RCSB]</span>
[https://www.uniprot.org/uniprot/SSB_ECOLI SSB_ECOLI] This protein is essential for replication of the chromosomes and its single-stranded DNA phages. It is also involved in DNA recombination and repair.
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/1kaw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kaw ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)'''
==See Also==
 
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of the tetrameric DNA-binding domain of the single-stranded DNA binding protein from Escherichia coli was determined at a resolution of 2.9 A using multiwavelength anomalous dispersion. Each monomer in the tetramer is topologically similar to an oligomer-binding fold. Two monomers each contribute three beta-strands to a single six-stranded beta-sheet to form a dimer. Two dimer-dimer interfaces are observed within the crystal. One of these stabilizes the tetramer in solution. The other interface promotes a superhelical structure within the crystal that may reflect tetramer-tetramer interactions involved in the positive cooperative binding of the single-stranded DNA-binding protein to single-stranded DNA.
 
==About this Structure==
1KAW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAW OCA].
 
==Reference==
Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution., Raghunathan S, Ricard CS, Lohman TM, Waksman G, Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6652-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9192620 9192620]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Raghunathan, S.]]
[[Category: Raghunathan S]]
[[Category: Waksman, G.]]
[[Category: Waksman G]]
[[Category: dna-binding protein]]
[[Category: single stranded dna binding protein]]
[[Category: ssb]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:45:53 2008''

Latest revision as of 07:45, 7 February 2024

STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)

1kaw, resolution 2.90Å

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