5gow: Difference between revisions
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==Solution structure of the complex between DP1 acidic region and TFIIH p62 PH domain== | |||
<StructureSection load='5gow' size='340' side='right'caption='[[5gow]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GOW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gow OCA], [https://pdbe.org/5gow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gow RCSB], [https://www.ebi.ac.uk/pdbsum/5gow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gow ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TFDP1_HUMAN TFDP1_HUMAN] Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).<ref>PMID:20176812</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Nishimura Y]] | |||
[[Category: Okuda M]] | |||
Latest revision as of 07:23, 1 May 2024
Solution structure of the complex between DP1 acidic region and TFIIH p62 PH domain
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