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[[Image:1ken.gif|left|200px]]


{{Structure
==INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION==
|PDB= 1ken |SIZE=350|CAPTION= <scene name='initialview01'>1ken</scene>, resolution 3.50&Aring;
<StructureSection load='1ken' size='340' side='right'caption='[[1ken]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
<table><tr><td colspan='2'>[[1ken]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/X-31(H3N2)) Influenza A virus (A/X-31(H3N2))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KEN FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ken FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ken OCA], [https://pdbe.org/1ken PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ken RCSB], [https://www.ebi.ac.uk/pdbsum/1ken PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ken ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ken FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ken OCA], [http://www.ebi.ac.uk/pdbsum/1ken PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ken RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/1ken_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ken ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.


'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''
An antibody that prevents the hemagglutinin low pH fusogenic transition.,Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M Virology. 2002 Mar 1;294(1):70-4. PMID:11886266<ref>PMID:11886266</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ken" style="background-color:#fffaf0;"></div>


==Overview==
==See Also==
We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.
*[[Antibody 3D structures|Antibody 3D structures]]
 
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
==About this Structure==
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
1KEN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KEN OCA].
== References ==
 
<references/>
==Reference==
__TOC__
An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11886266 11886266]
</StructureSection>
[[Category: Influenza a virus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Barbey-Martin C]]
[[Category: Barbey-Martin, C.]]
[[Category: Bizebard T]]
[[Category: Bizebard, T.]]
[[Category: Calder LJ]]
[[Category: Calder, L J.]]
[[Category: Gigant B]]
[[Category: Gigant, B.]]
[[Category: Knossow M]]
[[Category: Knossow, M.]]
[[Category: Skehel JJ]]
[[Category: Skehel, J J.]]
[[Category: Wharto SA]]
[[Category: Wharto, S A.]]
[[Category: envelope protein]]
[[Category: glycoprotein]]
[[Category: hemagglutinin]]
 
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Retrieved from "https://proteopedia.org/1ken"