5g42: Difference between revisions

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==Ligand complex of RORg LBD==
==Ligand complex of RORg LBD==
<StructureSection load='5g42' size='340' side='right' caption='[[5g42]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='5g42' size='340' side='right'caption='[[5g42]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5g42]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G42 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5g42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G42 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4TU:5-CHLORANYL-2,3-DIHYDROINDOLE-1-CARBOXAMIDE'>4TU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g43|5g43]], [[5g44|5g44]], [[5g45|5g45]], [[5g46|5g46]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4TU:5-CHLORANYL-2,3-DIHYDROINDOLE-1-CARBOXAMIDE'>4TU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g42 OCA], [http://pdbe.org/5g42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g42 RCSB], [http://www.ebi.ac.uk/pdbsum/5g42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g42 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g42 OCA], [https://pdbe.org/5g42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g42 RCSB], [https://www.ebi.ac.uk/pdbsum/5g42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g42 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.  
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Guo, H]]
[[Category: Homo sapiens]]
[[Category: Hillertz, P]]
[[Category: Large Structures]]
[[Category: Xue, Y]]
[[Category: Guo H]]
[[Category: Dna binding protein]]
[[Category: Hillertz P]]
[[Category: Fragment screen]]
[[Category: Xue Y]]
[[Category: Rorg ligand]]
[[Category: Simultaneous binding]]
[[Category: Structure-based design]]
Retrieved from "https://proteopedia.org/5g42"