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==Structure of the star domain of quaking protein in complex with RNA==
==Structure of the star domain of quaking protein in complex with RNA==
<StructureSection load='4jvh' size='340' side='right' caption='[[4jvh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4jvh' size='340' side='right'caption='[[4jvh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JVH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.501&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jvy|4jvy]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [https://pdbe.org/4jvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [https://www.ebi.ac.uk/pdbsum/4jvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvh ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">QKI, HKQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [http://pdbe.org/4jvh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [http://www.ebi.ac.uk/pdbsum/4jvh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN]] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>
[https://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Essig, K]]
[[Category: Large Structures]]
[[Category: Hafner, M]]
[[Category: Essig K]]
[[Category: Patel, D J]]
[[Category: Hafner M]]
[[Category: Teplov, D]]
[[Category: Patel DJ]]
[[Category: Teplova, M]]
[[Category: Teplov D]]
[[Category: Tuschl, T]]
[[Category: Teplova M]]
[[Category: Rna binding protein]]
[[Category: Tuschl T]]
[[Category: Rna regulator]]
[[Category: Star domain]]
[[Category: Translation]]
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